It is good practice to use a camel's hair brush or its equivalent to dust the balance pan before any weighing so as to remove any materials that may have been left by the previous operator. USP General Chapter 41 "Balances" is mandatory and states the requirements for balances used for materials that must be accurately weighed. Take appropriate size butter paper/receiver of with respect to the quantity of sample. Box containing standard weights Traceability of calibration weight standards Defines ‘the requirement for balances used to weigh analytes for quantitative measures’. If necessary, turn on the power, and allow the balance to equilibrate for at least 30 minutes before proceeding with the calibration. QUALITY ASSURANCE PROCEDURE FOR MEASUREMENT OF BALANCE DRIFT. If solids are spilled, remove the receiver, and sweep out all of the spilled material from the balance. Transfer approximate required quantity of semi-solid material to the glass coverslip with the help of a capillary tube or spatula. Place the empty butter paper / or receiver on the balance in the center of the pan, and press the appropriate tare (Zero) key on the balance (On stabilization of indicator). Perform 10 measurements with the exact same weight; Calculate 2 x the standard deviation (std. Electronic analytical balances have an internal calibration system based on an applied load. Materials must be brought to the temperature of the balance before they are weighed. Check that balance is exactly in a horizontal position, compensate it if any minor unevenness in its location by turning two leveling feet at the rear of the balance housing until the air bubble is in the center of the leveling control (internal circle). Hysteresis in the balance is caused by excessive stretching of the springs, and it is primarily due to overloading or to the accidental dropping of an object onto the pan. Carry out the same procedure for 200 g weight. USP<1251> Weighing on an analytical balance. This operation electrically sets the signal from the strain gauge to zero so that the weight of the receiver is no longer indicated. If the empty receiver is not going to be tared, add the material to the receiver, and place the receiver on the balance in the center of the pan. Email: Purified Water Loop – Operation & Maintenance SOP, Dissolution Apparatus – Operation & Calibration SOP, Refrigerator – Operation & Performance Check, Sampling of Packaging Materials – Procedure, Acceptable Quality Level (AQL) – SOP and Chart, Isolation and Identification of Microorganisms, Process Standardization and Validation – SOP, Stability Study Protocol and Specification – SOP, Handling of Returned Raw & Packing Material – SOP, User Requirement Specification (URS) Handling SOP, SOP for Review of Analytical Report and Raw Data, Microbiologist Qualification : SOP & Protocol, Analytical Method Validation (AMV) Procedure / Guide, Swab Test analysis of Equipment / Instrument – SOP. Adjust the level, if not leveled. Remove powder if any, from inside the balance using soft nylon brush & wipe with clean cotton balls. The modified USP Chapter 41 standard states, ‘Repeatability is assessed by weighing one test weight NLT 10 times. Record the weight and transfer the weighed material to the final flask or beaker as per requirements, Then reweigh the original weighing butter paper / or receiver by placing it in the same position on the pan. Do not allow the material to remain on the balance for an extended period of time because changes, caused by interaction with atmospheric water or carbon dioxide, may take place. Correct it by turning leveling feet until the level bubble is in the center of the indicator. Clean the weighing pan and close the draft shield. Each type requires special attention. Add the desired amount of material to the receiver. Weighing paper may be used for solids. Where “ d” is the scale interval (readability ) of the balance. Weighing is a frequent step in analytical procedures, and the balance is an essential piece of laboratory equipment in most analyses. After the receipt of the calibrated weight box along with the calibration certificate limit for allowable tolerance limit (for external calibration) should be calculated as minimum and maximum weight from the limit in terms of % mentioned in Attachment-1 for all the weight which require for the calibration. USP General Chapter 41 (Balances) General Chapter 41 sets three distinct requirements to be applied to materials that must be accurately weighed. Similarly, Reprint Annexure -2 and implemented including the following. Dispense weighing is used for weighing of emulsions or viscous liquids such as ointments. If the weight print facility of balance is not working, then inform the service engineer for rectification of this problem. Wipe the carefully inner side of the balance with clean moist cotton with 70% IPA solution in water, without disturbing the balance & finally mop with clean dry cotton. If the standard deviation obtained is less than 0.41d, where d is the scale interval, replace this standard deviation with 0.41d. Connect the power supply of instrument with the mains and turn power switch “ON”. The second weight represents the sum of the weights of the receiver and the untransferred material; subtract this sum from the sum of the total material weight and the receiver weight to determine the weight of the transferred material. Switch on the main power supply of the balance. As per USP, balance calibration parameters are Internal adjustments, Linearity, Sensitivity, Repeatability (Uncertainty), and Accuracy, etc. If the standard deviation is less than 0.41 digit (0.041 milligram (mg) for an analytical balance with a readability of 0.1 mg), replace it with 0.41 d so you can achieve the smallest possible starting point of an operating range of up to 820 d (2 * 0.41*1,000). SOP for Maintenance of Laboratory Instruments. If a deviation greater than those indicated below for. MONTHLY CALIBRATION Set the standard weights for various balances based on the capacity of the balance as mentioned in table – I. Calibration weights being used in the Accuracy check must have an accuracy of NMT 1/3 of the balance tolerance for that respective test point. All other things being equal, a vessel of low mass should be chosen when small amounts of material are to be weighed. The weights used for calibration shall be calibrated against standard weights traceable to. In accordance with section 7.05(c) of the 2010–2015 Rules and Procedures of the Council of Experts, this is to provide notice that the USP General Chapters—Physical Analysis Expert Committee intends to revise General Chapter <41> Balances to correct a problem detected with the Repeatability test. Calculate the measurement of uncertainty as follows. In addition, the tolerance does not correspond to the value of 0.1%, specified under Weights and Balances 41, for weighing material accurately. They are recommended for calibration of balances using optical or electrical methods for accurately weighing quantities below 20 mg. e.g. Every time after calibration of weight box format of. Common receivers are weighing bottles, weighing funnels, flasks, and weighing paper. New requirement to use a calibrated balance. King perform balance calibration per USP Chapter 41, our ISO17025 certificate conveniently provides the calibration data table, standard deviation, and the minimum allowable weight that your balance can accurately weigh. SOP for Preparation of internal and external (Third Party) Calibration schedule and calibration practices. Class 1.1 weights are used for calibration of low-capacity, high-sensitivity balances. It must have a constant electrical supply. The upper end of the working range is limited by the maximum weighing capacity and the lower range begins from a starting point at which the repeatability is less than or equal to 0.10%. For a gas-tight vessel, the analyst shall tare the vessel and enclosure, add the desired amount of sample in the vessel and replace the enclosure and record the weight. Check the level of the balance with the help of spirit level. The receiver's weight plus the weight to be measured must not exceed the maximum load for the balance; the size and shape of the receiver should permit it to fit into the space and on the balance pan without interfering with any operation. If any unevenness is observed in its location. If large chunks with a powdery surface are to be weighed, at least a piece of weighing paper must be placed on the balance pan to protect it from damage. The correct receiver depends upon the quantity and type of material (liquid, solid, or powder) to be weighed. The balance should be tested using weights traceable to standardization by the National Institute of Standards and Technology. In the event of a spill re-qualification of balance may require, depending on the nature of the spill. The observed balance reading should be within +/- 0.1% of market value of standard weight as per USP 41 requirements. Brady Systems is one of the largest distributors representing METTLER TOLEDO in North America. Perform the weighing of the sterile or bio-hazardous samples within the confines of the clean bench, biosafety cabinet, isolator or similar containment device. USP 37 Physical Tests / 〈791〉 pH 1 BUFFER SOLUTIONS FOR STANDARDIZATION 〈791〉 pH OF THE pH METER Buffer Solutions for Standardization are to be prepared as directed in the accompanying table. The first person to use the balance each day should weigh the check-weight and record the weight in the log book for comparison with previous readings. Air currents should not present near the balance. On stabilization of indicator record the displayed weight (Display weight shall be printed and keep with the raw data ) and transfer the glass coverslip directly into the receiver. No repairs should be made to any balance by anyone other than a qualified maintenance person. Weighing funnels come in various sizes; the size suitable for the operation should be selected. The analyst shall always use the calibrated weight box for calibration purposes. Transfer the desired amount of material to the final flask or beaker as per requirements, then reweigh the sample container by placing back on the pan of balance [ Note- Do not change the set tare of the balance between these two weighings]. Many chemicals, such as salts are corrosive, and material of this nature should not spill on the balance pan or inside the balance housing. Take fresh standard/ sample weights for the batch to continue the analysis. SOP for Instrument / Equipment usage log book. Enjoy the videos and music you love, upload original content, and share it all with friends, family, and the world on YouTube. Place the clean and dry glass coverslip on the balance in the center of the pan and press the appropriate tare (Zero) key on the balance (On stabilization of indicator). If stretching of the springs is excessive, an expensive balance overhaul may be needed. However, it is important for each balance to be serviced and calibrated regularly by a specially trained internal or external service person. Press the “Print” key from the menu bar, to take a printout of the printer is attached. In the revised version of Chapter 41 of the USP, the working range of a balance needs to be determined instead of the minimum initial weight. Record the observations in the balance calibration record. Analytical Balance Calibration (Updated) Procedure to calibrate the Analytical Weighing Balance as Drift check, Performance check and Measurement uncertainty check as per USP. 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